macOS 12.3 Monterey brings Metal support to Blender and my 2020 iMac with AMD graphics and there is the first OCIO V2 config that I somehow get to run in Blender 3.2 Alpha.
Here is a small setup guide to run Blender and the new OCIO V2 pre-release config. As the names indicate, it’s all Alpha and Beta so expect issues and bugs.